neuropeptides (sp and cgrp) augment il-1 beta production in hsv-infected macrophages
نویسندگان
چکیده
neuropeptides, possessing specific and functional receptors on various cells of the immune system, have the potential to regulate immune responses; and the macrophages as important components of defense against various agents, are at their influence. in this study the effect of neuropeptides substance p (sp) and calcitonin gene-related peptide (cgrp) on il-1 beta production by herpes sim¬plex type-1 (hsv-1 )-infected and also uninfected mouse peritoneal macrophages were considered. each neuropeptide separately has upregulated il-1 beta produc¬tion by hsv-1 infected macrophages with the greatest effect at the concentrations of 10'9m for both sp and cgrp, but no synergistic effect on il-1 production has been observed in the presence of both neuropeptides at optimal concentrations. il-ip production by uninfected macrophages was also moderately enhanced in the presence of each neuropeptide, but not in the presence of both neuropeptides simultaneously. it can be concluded that il-1 s3 production, which is part of mac¬rophage mediated inflammatory response to hsv-1, is enhanced by specific doses of neuropeptides.
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عنوان ژورنال:
iranian journal of allergy, asthma and immunologyجلد ۲، شماره ۲، صفحات ۹۵-۱۰۰
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